amyotrophic lateral sclerosis

noun

amyo·​tro·​phic lateral sclerosis ˌā-ˌmī-ə-ˈtrō-fik- How to pronounce amyotrophic lateral sclerosis (audio) -ˈträ- How to pronounce amyotrophic lateral sclerosis (audio)
: a rare progressive degenerative fatal disease affecting the motor neurons, usually beginning in middle age, and characterized especially by increasing and spreading muscular weakness and atrophy
abbreviation ALS

called also Lou Gehrig's disease

Examples of amyotrophic lateral sclerosis in a Sentence

Recent Examples on the Web
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Chris Johnson, the former NFL running back who holds the record for most yards from scrimmage in a single season, has the degenerative neurological disorder amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig’s disease. Chuck Schilken, Los Angeles Times, 29 June 2026 The Euphoria star, who died at 53 years old, 10 months after revealing his amyotrophic lateral sclerosis (ALS) diagnosis. Kayla Grant, PEOPLE, 22 June 2026 Deny, who played JVMA CEO and fashion boss Louis de Léon in the Lily Collins-starring drama, died on May 25 after a battle with amyotrophic lateral sclerosis (ALS), his family confirmed in a statement to TF1, the French broadcaster. Etan Vlessing, HollywoodReporter, 27 May 2026 Lou Gehrig was added later that year due to amyotrophic lateral sclerosis (ALS) ending his career. USA Today, 27 May 2026 See All Example Sentences for amyotrophic lateral sclerosis

Word History

Etymology

translation of French sclérose latérale amyotrophique; amyotrophique "marked by atrophy of a muscle" from a- a- entry 2 + myo- myo- + -trophique -trophic

First Known Use

1875, in the meaning defined above

Time Traveler
The first known use of amyotrophic lateral sclerosis was in 1875

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Cite this Entry

“Amyotrophic lateral sclerosis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/amyotrophic%20lateral%20sclerosis. Accessed 5 Jul. 2026.

Medical Definition

amyotrophic lateral sclerosis

noun
: a rare fatal progressive degenerative disease that affects pyramidal motor neurons, usually begins in middle age, and is characterized especially by increasing and spreading muscular weakness
abbreviation ALS

called also Lou Gehrig's disease

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